Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …

Photoacoustic (PA) imaging has emerged as a powerful technique for the high resolution
visualization of biological processes within deep tissue. Through the development and …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Immune checkpoint therapy has achieved significant efficacy by blocking inhibitory
pathways to release the function of T lymphocytes. In the clinic, anti-programmed cell death …

Background Contemporary deep learning approaches show cutting-edge performance in a
variety of complex prediction tasks. Nonetheless, the application of deep learning in …

Normal tissue homeostasis and architecture restrain tumor growth. Thus, for a tumor to
develop and spread, malignant cells must overcome growth-repressive inputs from …

Biological tissues are not uniquely composed of cells. A substantial part of their volume is
extracellular space, which is primarily filled by an intricate network of macromolecules …

Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …

The development of cancer immunotherapy, particularly immune checkpoint blockade
therapy, has made major breakthroughs in the therapy of cancers. However, less than one …

Metastasis is a major contributor to cancer-associated deaths. It involves complex
interactions between primary tumorigenic sites and future metastatic sites. Accumulation …