[HTML][HTML] Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors
Abstract Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases
(PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated …
(PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated …
A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective
J Wang, F Gong, T Liang, Z Xie, Y Yang, C Cao… - European Journal of …, 2021 - Elsevier
Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …
products (NPs) and synthetic compounds which show a variety of pharmacological activities …
Development of a new drug candidate for the inhibition of Lassa virus glycoprotein and nucleoprotein by modification of evodiamine as promising therapeutic agents
The Lassa virus (LASV), an RNA virus prevalent in West and Central Africa, causes severe
hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or …
hemorrhagic fever with a high fatality rate. However, no FDA-approved treatments or …
Mangostanin derivatives as novel and orally active phosphodiesterase 4 inhibitors for the treatment of idiopathic pulmonary fibrosis with improved safety
YY Huang, J Deng, YJ Tian, J Liang, X Xie… - Journal of Medicinal …, 2021 - ACS Publications
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease, and its incidence rate is
rapidly rising. However, effective therapies for the treatment of IPF are still lacking …
rapidly rising. However, effective therapies for the treatment of IPF are still lacking …
Therapy for pulmonary arterial hypertension: Glance on nitric oxide pathway
A Tettey, Y Jiang, X Li, Y Li - Frontiers in pharmacology, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a severe disease with a resultant increase of the
mean pulmonary arterial pressure, right ventricular hypertrophy and eventual death …
mean pulmonary arterial pressure, right ventricular hypertrophy and eventual death …
Design, synthesis and bioactivity study of evodiamine derivatives as multifunctional agents for the treatment of hepatocellular carcinoma
X Fan, J Deng, T Shi, H Wen, J Li, Z Liang, F Lei… - Bioorganic …, 2021 - Elsevier
Topoisomerase has been found extremely high level of expression in hepatocellular
carcinoma (HCC) and proven to promote the proliferation and survival of HCC. Cancer …
carcinoma (HCC) and proven to promote the proliferation and survival of HCC. Cancer …
Design, synthesis, and biological evaluation of novel evodiamine derivatives as potential antihepatocellular carcinoma agents
F Lei, Y Xiong, Y Wang, H Zhang, Z Liang… - Journal of Medicinal …, 2022 - ACS Publications
Evodiamine has many biological activities. Herein, we synthesize 23 disubstituted
derivatives of N14-phenyl or the E-ring of evodiamine and conduct systematic structure …
derivatives of N14-phenyl or the E-ring of evodiamine and conduct systematic structure …
Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases
H Liu, Q Wang, Y Huang, J Deng, X Xie, J Zhu… - European Journal of …, 2022 - Elsevier
Abstract Inflammatory Bowel Diseases (IBDs) are chronic disorders with iterative intestinal
mucosal inflammation which remain unmet medical needs. PDE4 inhibitors were reported to …
mucosal inflammation which remain unmet medical needs. PDE4 inhibitors were reported to …
Strategy to Construct Polycyclic Scaffolds via Formal Aza‐Diels‐Alder Reaction of Dihydro‐β‐Carboline with Heterodiene Precursor
X Zhang, J Wei, M Zhu, D Yang, Y Pan… - Advanced Synthesis …, 2023 - Wiley Online Library
Strategy to Construct Polycyclic Scaffolds via Formal Azaâ•’Dielsâ•’Alder Reaction of
Dihydro╒β╒Carbo Page 1 Title: Strategy to Construct Polycyclic Scaffolds via Formal AzaDiels-Alder …
Dihydro╒β╒Carbo Page 1 Title: Strategy to Construct Polycyclic Scaffolds via Formal AzaDiels-Alder …
Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy
Z Liang, Y Wang, H Zhang, J Deng, F Lei, J Li… - European journal of …, 2022 - Elsevier
Natural product evodiamine is one of the most privileged scaffolds in drug discovery and is
suitable for derivatization, which can be conducted quickly for structure optimization and …
suitable for derivatization, which can be conducted quickly for structure optimization and …