COVID‐19 vaccine adverse events: Evaluating the pathophysiology with an emphasis on sulfur metabolism and endotheliopathy

HN du Preez, J Lin, GEM Maguire… - European Journal of …, 2024 - Wiley Online Library
In this narrative review, we assess the pathophysiology of severe adverse events that
presented after vaccination with DNA and mRNA vaccines against COVID‐19. The focus is …

The Ways of the Virus: Interactions of Platelets and Red Blood Cells with SARS-CoV-2, and Their Potential Pathophysiological Significance in COVID-19

MA Panteleev, AN Sveshnikova… - International Journal of …, 2023 - mdpi.com
The hematological effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) are important in COVID-19 pathophysiology. However, the interactions of SARS-CoV-2 …

Short Survey on the Protein Modifications in Plasma during SARS-CoV-2 Infection

A Gęgotek, N Zarkovic, B Orehovec… - International journal of …, 2023 - mdpi.com
Although the COVID-19 pandemic has ended, it is important to understand the pathology of
severe SARS-CoV-2 infection associated with respiratory failure and high mortality. The …

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB

V Monaco, I Iacobucci, L Canè, I Cipollone… - International Journal of …, 2024 - Elsevier
Abstract The SARS-CoV-2 pandemic, responsible for approximately 7 million deaths
worldwide, highlights the urgent need to understand the molecular mechanisms of the virus …

Impaired instructive and protective barrier functions of the endothelial cell glycocalyx pericellular matrix is impacted in COVID‐19 disease

MS Margaret, J Melrose - Journal of Cellular and Molecular …, 2024 - Wiley Online Library
The aim of this study was to review the roles of endothelial cells in normal tissue function
and to show how COVID‐19 disease impacts on endothelial cell properties that lead to …

Special Issue “COVID-19 Coagulopathy: Advances on Pathophysiology and Therapies”

E Russu, EM Arbănaşi, A Șchiopu - International Journal of Molecular …, 2024 - mdpi.com
The Special Issue on COVID-19 coagulopathy initiated one year ago aimed to shed light on
the mechanisms underlying the changes in the coagulation status making SARS-CoV-2 …

Recombinant Rod Domain of Vimentin Reduces SARS-CoV-2 Viral Replication by Blocking Spike Protein–ACE2 Interactions

FW Lam, CA Brown, SE Ronca - International Journal of Molecular …, 2024 - mdpi.com
Although the SARS-CoV-2 vaccination is the primary preventive intervention, there are still
few antiviral therapies available, with current drugs decreasing viral replication once the …

SARS-CoV-2 spike protein receptor binding domain promotes IL-6 and IL-8 release via ATP/P2Y2 and ERK1/2 signaling pathways in human bronchial epithelia

RG Zhang, XJ Liu, YL Guo, CL Chen - Molecular Immunology, 2024 - Elsevier
The spike protein of SARS-CoV-2 as well as its receptor binding domain (RBD) has been
demonstrated to be capable of activating the release of pro-inflammatory mediators in …

Symmetrical peripheral gangrene: potential mechanisms and therapeutic approaches in severe COVID-19

M Wang, T Sun, L Dong, S Huang, J Liu - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Symmetrical peripheral gangrene is a rare condition that is characterized by ischemic
damage and tissue death (gangrene) in the extremities. Recent reports have shed light on …

[HTML][HTML] Trivalent Disulfide Unit-Masked System Efficiently Delivers Large Oligonucleotide

L Wang, X Liu, Y Wu, Z Ye, Y Wang, S Gao, H Gong… - Molecules, 2024 - mdpi.com
Oligonucleotide drugs are shining in clinical therapeutics, but efficient and safe delivery
systems severely limit their widespread use. A disulfide unit technology platform based on …