Phytosterol and stanol (or phytosterols) consumption reduces intestinal cholesterol
absorption, leading to decreased blood LDL-cholesterol levels and lowered cardiovascular …

Breast cancer represents a highly heterogeneous disease comprised by several subtypes
with distinct histological features, underlying molecular etiology and clinical behaviors. It is …

The prognosis of breast cancer in young women is influenced by reproductive history.
Women diagnosed within 5 years postpartum have worse prognosis than nulliparous …

Cohesive scientific evidence from molecular, animal, and human investigations supports the
hypothesis that constitutive overexpression of cyclooxygenase-2 (COX-2) is a ubiquitous …

Breast cancer frequently metastasizes to the skeleton, interrupting the normal bone
remodeling process and causing bone degradation. Osteolytic lesions are the end result of …

Approximately 75% of breast tumors express the estrogen receptor (ER), and women with
these tumors will receive endocrine therapy. Unfortunately, up to 50% of these patients will …

The nitric oxide (NO) and cyclooxygenase (COX) pathways share a number of similarities.
Nitric oxide is the mediator generated from the NO synthase (NOS) pathway, and COX …

Metastasis is responsible for the majority of breast cancer-related deaths. The metastatic
spread of cancer cells is a complicated process that requires considerable flexibility in the …

Background High breast density is linked to an increased risk of breast cancer, and
correlates with changes in collagen. In a mouse model of mammary carcinoma in the context …

Cohesive scientific evidence from molecular, animal, and human investigations supports the
hypothesis that aberrant induction of COX-2 and up-regulation of the prostaglandin cascade …