The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …

Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …

Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic
chromosomes and thereby protect their stability and integrity. Telomeres play central roles in …

The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at
individual chromosome ends by the telomeric protein/DNA complex in a manner dependent …

Telomerase maintains chromosome ends from humans to yeasts. Recruitment of yeast
telomerase to telomeres occurs through its Ku and Est1 subunits via independent …

The intimate connection between telomerase regulation and human disease is now well
established. The molecular basis for telomerase regulation is highly complex and entails …

Elongation of telomeres by telomerase replenishes the loss of terminal telomeric DNA
repeats during each cell cycle. In budding yeast, Cdc13 plays an essential role in telomere …

(A) Deg1-β-galactosidase (β-gal),(B) myc-Hmg2, or (C) HA-Ubc6 were treated with or
without the proteasome inhibitor MG132 (75 μM). Time points were taken after expression …