Chemotherapeutic approaches to the treatment of the acquired immune deficiency syndrome (AIDS)

E De Clercq - Journal of Medicinal Chemistry, 1986 - ACS Publications
Acquired immunodeficiency syndrome (AIDS) was first recognized in 1981 as a distinct
clinical entity, 1 and soon after the infectious nature of the disease became apparent, human …

Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys

PJ Kanki, J Alroy, M Essex - Science, 1985 - science.org
Present evidence suggests that the acquired immune deficiency syndrome (AIDS) emerged
in Central Africa as a new disease in recent decades. This disease has recently approached …

Induction of anti‐HIV neutralizing antibodies by synthetic peptides.

TC Chanh, GR Dreesman, P Kanda, GP Linette… - The EMBO …, 1986 - embopress.org
Two synthetic peptides containing amino acid sequences analogous to the envelope
glycoprotein of human T‐lymphotropic virus (HTLV) type III (HTLV‐III) and lymphadenopathy …

Serological markers in early stages of human immunodeficiency virus infection in haemophiliacs

JP Allain, DA Paul, Y Laurian, D Senn… - The Lancet, 1986 - Elsevier
Immunoassays for human immunodeficiency virus antigen (HIV Ag) and for antibody to HIV
core and envelope (CIA-RA) were done on serial specimens from 40 haemophiliacs who …

Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.

JM Lange, DA Paul, HG Huisman, F de Wolf… - Br Med J (Clin Res …, 1986 - bmj.com
Sequential serum samples from 13 homosexual men who seroconverted for antibodies to
human immunodeficiency virus (HIV) were tested for HIV antigen. In one of these men, who …

Isolation of simian immunodeficiency virus from African green monkeys and seroepidemiologic survey of the virus in various non‐human primates

Y Ohta, T Masuda, H Tsujimoto… - … Journal of Cancer, 1988 - Wiley Online Library
Sixteen isolates of simian retrovirus closely related to human immunodeficiency virus (HIV)
were obtained from healthy African green monkeys (AGM)(Cercopithecus aethiops). The first …

Biologically diverse molecular variants within a single HIV-1 isolate

AG Fisher, B Ensoli, D Looney, A Rose, RC Gallo… - Nature, 1988 - nature.com
AIDS is a disorder characterized by a slow progressive impairment of immune function and
by infection of human immunodeficiency viruses (HIV-1, HIV-2) 1–4. Our knowledge of how …

Prospect for prevention of human immunodeficiency virus infection: purified 120-kDa envelope glycoprotein induces neutralizing antibody.

WG Robey, LO Arthur, TJ Matthews… - Proceedings of the …, 1986 - National Acad Sciences
This study initiates an effort to develop a safe vaccine against the acquired
immunodeficiency syndrome (AIDS) that is caused by infection with a retrovirus designated …

Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for …

SM Alam, RM Scearce, RJ Parks, K Plonk… - Journal of …, 2008 - Am Soc Microbiol
Two human monoclonal antibodies (MAbs)(2F5 and 4E10) against the human
immunodeficiency virus type 1 (HIV-1) envelope g41 cluster II membrane proximal external …

A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients

JS Allan, JE Coligan, TH Lee, MF McLane, PJ Kanki… - Science, 1985 - science.org
A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the
acquired immune deficiency syndrome, was studied. This protein, which has a molecular …