The innate immune system is the critical first line of defense against infectious and sterile
insults. A cell's ability to sense these insults relies on a series of germline-encoded …

Pyroptosis is a recently described mechanism of programmed cell death mediated by
proteins of the gasdermin family. Widely recognized signaling cascades include the …

Sepsis-associated acute kidney injury (SA-AKI) is common in patients with severe sepsis,
and has a high incidence rate and high mortality rate in ICU patients. Most patients progress …

Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …

Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …

Subarachnoid haemorrhage (SAH) is a common cerebrovascular disease with high
disability and mortality rates worldwide. The pathophysiological mechanisms involved in an …

Hair follicles (HFs) function as hubs for stem cells, immune cells, and commensal microbes,
which must be tightly regulated during homeostasis and transient inflammation. Here we …

The programmed cell death machinery exhibits surprising flexibility, capable of crosstalk and
non-apoptotic roles. Much of this complexity arises from the diverse functions of caspase-8 …

Sepsis is a systemic inflammatory response syndrome caused by infection, following with
acute injury to multiple organs. Sepsis-induced acute kidney injury (AKI) is currently …

Caspases are intimately associated with altering various signaling pathways, resulting in
programmed cell death or apoptosis. Apoptosis is necessary for the normal homeostasis of …