Host-microbiota interactions involving inflammatory and metabolic pathways have been
linked to the pathogenesis of multiple immune-mediated diseases and metabolic conditions …

Despite milestones in preventive measures and treatment, cardiovascular disease (CVD)
remains associated with a high burden of morbidity and mortality. The protracted nature of …

Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

Study question What is the association between clarithromycin use and cardiovascular
outcomes? Methods In this population based study the authors compared cardiovascular …

Background Randomised clinical trials are key to advancing medical knowledge and to
enhancing patient care, but major barriers to their conduct exist. The present paper presents …

Background Macrolide antibiotics (macrolides) are among the most commonly prescribed
antibiotics worldwide and are used for a wide range of infections. However, macrolides also …

There are numerous disorders of known or presumed neurologic origin that result in
excessive daytime sleepiness, collectively known as the central disorders of …

Rationale: The overuse of antibiotics has been an important clinical issue, and antibiotic
exposure is linked to alterations in gut microbiota, which has been related to risks of various …

Heart failure with preserved ejection fraction (HFpEF) is a disease for which there is no
definite and effective treatment, and the number of patients is more than 50% of heart failure …

Background: The nasal microbiome represents the main environmental factor of the
inflammatory process in chronic rhinosinusitis (CRS). Antibiotics and steroids constitute the …