Mitochondria are well known as the centre of energy metabolism in eukaryotic cells.
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …

Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …

Coenzyme Q (or ubiquinone) is a redox-active lipid that serves as universal electron carrier
in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid …

Introduction Radiotherapy is a mainstay of cancer treatment. Clinical studies revealed a
heterogenous response to radiotherapy, from a complete response to even disease …

Diabetes and Alzheimer's disease are common chronic illnesses in the United States and
lack clearly demonstrated therapeutics. Mitochondria, the “powerhouse of the cell”, is …

Neurological disorders affect the nervous system. Biochemical, structural, or electrical
abnormalities in the spinal cord, brain, or other nerves lead to different symptoms, including …

Coenzyme Q (CoQ) is a redox-active lipid essential for core metabolic pathways and
antioxidant defense. CoQ is synthesized upon the mitochondrial inner membrane by an ill …

Introduction: Although several meta-analyses support the positive effect of coenzyme Q10
(CoQ10) on biomarkers of oxidative stress and inflammation, the results of some other …

The progress in understanding the pathogenesis and treatment of Alzheimer's disease (AD)
is based on the recognition of the primary causes of the disease, which can be deduced …

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an
expansion in CAG repeat on huntington (Htt) gene, leading to a degeneration of GABAergic …