Tau in physiology and pathology
Y Wang, E Mandelkow - Nature reviews neuroscience, 2016 - nature.com
Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …
Lasting impact of general anaesthesia on the brain: mechanisms and relevance
L Vutskits, Z Xie - Nature Reviews Neuroscience, 2016 - nature.com
General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …
the performance of surgery under optimal conditions. An increasing number of clinical and …
[HTML][HTML] Anesthesiology and cognitive impairment: a narrative review of current clinical literature
JC Belrose, RR Noppens - BMC anesthesiology, 2019 - Springer
Background The impact of general anesthesia on cognitive impairment is controversial and
complex. A large body of evidence supports the association between exposure to surgery …
complex. A large body of evidence supports the association between exposure to surgery …
Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice
The microtubule-associated protein tau has been implicated in the pathogenesis of
Alzheimer's disease (AD) and other neurodegenerative disorders. Reducing tau levels …
Alzheimer's disease (AD) and other neurodegenerative disorders. Reducing tau levels …
[HTML][HTML] What is the evidence that tau pathology spreads through prion-like propagation?
Emerging experimental evidence suggests that the spread of tau pathology in the brain in
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …
Tauopathies reflects the propagation of abnormal tau species along neuroanatomically …
BIS-guided anesthesia decreases postoperative delirium and cognitive decline
Background: Previous clinical trials and animal experiments have suggested that long-
lasting neurotoxicity of general anesthetics may lead to postoperative cognitive dysfunction …
lasting neurotoxicity of general anesthetics may lead to postoperative cognitive dysfunction …
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
EM Mandelkow, E Mandelkow - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD),
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …
the neurofibrillary tangles, and is therefore of major interest as an indicator of disease …
Tau in Alzheimer disease and related tauopathies
Tau is the major microtubule associated protein (MAP) of a mature neuron. The other two
neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction …
neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction …
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
CA Tagge, AM Fisher, OV Minaeva… - Brain, 2018 - academic.oup.com
The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic
encephalopathy, and the relationships between these disorders, are poorly understood. We …
encephalopathy, and the relationships between these disorders, are poorly understood. We …
Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
H Zempel, E Mandelkow - Trends in neurosciences, 2014 - cell.com
Tau is a microtubule-associated-protein that is sorted into neuronal axons in physiological
conditions. In Alzheimer disease (AD) and other tauopathies, Tau sorting mechanisms fail …
conditions. In Alzheimer disease (AD) and other tauopathies, Tau sorting mechanisms fail …