[HTML][HTML] The health digital twin to tackle cardiovascular disease—a review of an emerging interdisciplinary field

G Coorey, GA Figtree, DF Fletcher, VJ Snelson… - NPJ digital …, 2022 - nature.com
Potential benefits of precision medicine in cardiovascular disease (CVD) include more
accurate phenotyping of individual patients with the same condition or presentation, using …

The openCARP simulation environment for cardiac electrophysiology

G Plank, A Loewe, A Neic, C Augustin… - Computer methods and …, 2021 - Elsevier
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

M Fedele, R Piersanti, F Regazzoni, M Salvador… - Computer Methods in …, 2023 - Elsevier
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023 - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

[HTML][HTML] A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

F Regazzoni, M Salvador, PC Africa, M Fedele… - Journal of …, 2022 - Elsevier
We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …

[HTML][HTML] Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators

M Strocchi, S Longobardi, CM Augustin… - PLoS Computational …, 2023 - journals.plos.org
Cardiac pump function arises from a series of highly orchestrated events across multiple
scales. Computational electromechanics can encode these events in physics-constrained …

[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

R Piersanti, F Regazzoni, M Salvador, AF Corno… - Computer Methods in …, 2022 - Elsevier
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …

[HTML][HTML] Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

M Salvador, M Fedele, PC Africa, E Sung… - Computers in Biology …, 2021 - Elsevier
We developed a novel patient-specific computational model for the numerical simulation of
ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

[HTML][HTML] A personalized real-time virtual model of whole heart electrophysiology

K Gillette, MAF Gsell, M Strocchi, T Grandits… - Frontiers in …, 2022 - frontiersin.org
Computer models capable of representing the intrinsic personal electrophysiology (EP) of
the heart in silico are termed virtual heart technologies. When anatomy and EP are tailored …