[HTML][HTML] The health digital twin to tackle cardiovascular disease—a review of an emerging interdisciplinary field
G Coorey, GA Figtree, DF Fletcher, VJ Snelson… - NPJ digital …, 2022 - nature.com
Potential benefits of precision medicine in cardiovascular disease (CVD) include more
accurate phenotyping of individual patients with the same condition or presentation, using …
accurate phenotyping of individual patients with the same condition or presentation, using …
The openCARP simulation environment for cardiac electrophysiology
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …
long and rich tradition of computational modeling. Nevertheless, no community standard for …
[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …
pathological conditions, four-chamber heart models have only been addressed recently; …
A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …
[HTML][HTML] A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation
We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …
wherein biophysically detailed core models describe the different physical processes …
[HTML][HTML] Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators
Cardiac pump function arises from a series of highly orchestrated events across multiple
scales. Computational electromechanics can encode these events in physics-constrained …
scales. Computational electromechanics can encode these events in physics-constrained …
[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …
[HTML][HTML] Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia
We developed a novel patient-specific computational model for the numerical simulation of
ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model …
ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This model …
[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …
describe the hemodynamics of the whole human heart, driven by a four-chamber …
[HTML][HTML] A personalized real-time virtual model of whole heart electrophysiology
Computer models capable of representing the intrinsic personal electrophysiology (EP) of
the heart in silico are termed virtual heart technologies. When anatomy and EP are tailored …
the heart in silico are termed virtual heart technologies. When anatomy and EP are tailored …