The role of mitochondria in acute kidney injury and chronic kidney disease and its therapeutic potential

X Zhang, E Agborbesong, X Li - International journal of molecular …, 2021 - mdpi.com
Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Mitochondrial dysfunction: roles in skeletal muscle atrophy

X Chen, Y Ji, R Liu, X Zhu, K Wang, X Yang… - Journal of Translational …, 2023 - Springer
Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Transition of acute kidney injury to chronic kidney disease: role of metabolic reprogramming

Z Zhu, J Hu, Z Chen, J Feng, X Yang, W Liang, G Ding - Metabolism, 2022 - Elsevier
Acute kidney injury (AKI) is a global public health concern associated with high morbidity
and mortality. Although advances in medical management have improved the in-hospital …

[HTML][HTML] Podocyte injury of diabetic nephropathy: novel mechanism discovery and therapeutic prospects

X Li, Y Zhang, X Xing, M Li, Y Liu, A Xu… - Biomedicine & …, 2023 - Elsevier
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, posing significant
challenges in terms of early prevention, clinical diagnosis, and treatment. Consequently, it …

Folic acid‐induced animal model of kidney disease

LJ Yan - Animal models and experimental medicine, 2021 - Wiley Online Library
The kidneys are a vital organ that is vulnerable to both acute kidney injury (AKI) and chronic
kidney disease (CKD) which can be caused by numerous risk factors such as ischemia …

[HTML][HTML] Gut microbiota dysbiosis in AKI to CKD transition

GR Saranya, P Viswanathan - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Background and aim The symptoms of acute kidney injury (AKI) include a sudden drop-in
glomerular filtration rate (GFR), a rise in serum creatinine (sCr), blood urea nitrogen (BUN) …

Delayed graft function in kidney transplant: risk factors, consequences and prevention strategies

C Ponticelli, F Reggiani, G Moroni - Journal of personalized medicine, 2022 - mdpi.com
Background. Delayed graft function is a frequent complication of kidney transplantation that
requires dialysis in the first week posttransplant. Materials and Methods. We searched for …

Oxidative stress and mitochondrial dysfunction in chronic kidney disease

HJ Ho, H Shirakawa - Cells, 2022 - mdpi.com
The kidney contains many mitochondria that generate ATP to provide energy for cellular
processes. Oxidative stress injury can be caused by impaired mitochondria with excessive …

Long-term effects of severe burns on the kidneys: research advances and potential therapeutic approaches

G Yang, L Tan, H Yao, Z Xiong, J Wu… - Journal of Inflammation …, 2023 - Taylor & Francis
Burns are a seriously underestimated form of trauma that not only damage the skin system
but also cause various complications, such as acute kidney injury (AKI). Recent clinical …

Podocyte injury in diabetic kidney disease: a focus on mitochondrial dysfunction

S Liu, Y Yuan, Y Xue, C Xing, B Zhang - Frontiers in Cell and …, 2022 - frontiersin.org
Podocytes are a crucial cellular component in maintaining the glomerular filtration barrier,
and their injury is the major determinant in the development of albuminuria and diabetic …