The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans
The metabolic investigation of the human population is becoming increasingly important in
the study of health and disease. The phenotypic variation can be investigated through the …
the study of health and disease. The phenotypic variation can be investigated through the …
Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta‐analysis
A Conde‐Agudelo, AT Papageorghiou… - … Journal of Obstetrics …, 2013 - Wiley Online Library
Background Several biomarkers for predicting intrauterine growth restriction (IUGR) have
been proposed in recent years. However, the predictive performance of these biomarkers …
been proposed in recent years. However, the predictive performance of these biomarkers …
[HTML][HTML] Per-and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle …
Background Prenatal exposures to per-and polyfluoroalkyl substances (PFAS) have been
linked to reduced fetal growth. However, the detailed molecular mechanisms remain largely …
linked to reduced fetal growth. However, the detailed molecular mechanisms remain largely …
Early nutrition programming of long-term health
Increasing evidence from the EU Project EARNEST and many other investigators
demonstrates that early nutrition and lifestyle have long-term effects on later health and the …
demonstrates that early nutrition and lifestyle have long-term effects on later health and the …
Developmental and early life origins of cardiometabolic risk factors: novel findings and implications
E Lurbe, J Ingelfinger - Hypertension, 2021 - Am Heart Assoc
The intent of this review is to critically consider the data that support the concept of
programming and its implications. Birth weight and growth trajectories during childhood are …
programming and its implications. Birth weight and growth trajectories during childhood are …
[HTML][HTML] Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery
DB Kell, R Goodacre - Drug Discovery Today, 2014 - Elsevier
Highlights•We now have metabolic network models; the metabolome is represented by their
nodes.•Metabolite levels are sensitive to changes in enzyme activities.•Drugs hitchhike on …
nodes.•Metabolite levels are sensitive to changes in enzyme activities.•Drugs hitchhike on …
Metabolomics Application in Maternal‐Fetal Medicine
Metabolomics in maternal‐fetal medicine is still an “embryonic” science. However, there is
already an increasing interest in metabolome of normal and complicated pregnancies, and …
already an increasing interest in metabolome of normal and complicated pregnancies, and …
UPLC-MS metabolic profiling of second trimester amniotic fluid and maternal urine and comparison with NMR spectral profiling for the identification of pregnancy …
G Graça, BJ Goodfellow, AS Barros, S Diaz… - Molecular …, 2012 - pubs.rsc.org
We report on the first untargeted UPLC-MS study of 2nd trimester maternal urine and
amniotic fluid (AF), to investigate the possible metabolic effects of fetal malformations (FM) …
amniotic fluid (AF), to investigate the possible metabolic effects of fetal malformations (FM) …
Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother–child cohort study
Background Preterm birth (PB) and fetal growth restriction (FGR) convey the highest risk of
perinatal mortality and morbidity, as well as increasing the chance of developing chronic …
perinatal mortality and morbidity, as well as increasing the chance of developing chronic …
[HTML][HTML] Hair metabolomics: identification of fetal compromise provides proof of concept for biomarker discovery
Abstract Analysis of the human metabolome has yielded valuable insights into health,
disease and toxicity. However, the metabolic profile of complex biological fluids such as …
disease and toxicity. However, the metabolic profile of complex biological fluids such as …