The use of non-standard toxicity models is a hurdle in the early development of antimicrobial
peptides towards clinical applications. Herein we report an extensive in vitro and in vivo …

The 3D structure and surface characteristics of proteins and peptides are crucial for
interactions with receptors or ligands and can be modified to some extent to modulate their …

Antimicrobial peptides have attracted considerable interest as potential new class of
antibiotics against multi-drug resistant bacteria. However, their therapeutic potential is …

The influence of hydrophobicity on antibacterial activity versus the effect on the viability of
mammalian cells for peptide/peptoid hybrids was examined for oligomers based on the …

Previous optimisation studies of peptide/peptoid hybrids typically comprise comparison of
structurally related analogues displaying different oligomer length and diverse side chains …

Integumentary infections like pyoderma represent the main reason for antimicrobial
prescription in dogs. Staphylococcus pseudintermedius and Pseudomonas aeruginosa are …

There is a pressing need to develop new antimicrobials to help combat the increase in
antibiotic resistance that is occurring worldwide. In the current research, short amphiphilic …

PEGylation of antimicrobial peptides as a shielding tool that increases stability toward
proteolytic degradation typically leads to concomitant loss of activity, whereas incorporation …

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) constitutes an emerging
health problem for companion animals in veterinary medicine. Therefore, discovery of novel …

A total of 100 canine wound samples of accidental wound (n= 40), pyoderma (n= 16), tail
wound (n= 15), localized anal wound (n= 10), otitis (n= 8), lacerated mammary wound (n= 6) …