Patients with inflammatory bowel disease (IBD) have increased incidence of colorectal
cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal …

The pathogenesis of inflammatory bowel disease (IBD) remains unclear and is associated
with an increased risk of developing colitis-associated cancer (CAC). Under sustained …

As an important immune stimulator and modulator, IFNγ is crucial for gut homeostasis and its
dysregulation links to diverse colon pathologies, such as colitis and colorectal cancer …

Purpose Loss of expression of DLG2 has been identified in a number of cancers to
contribute to the disease by resulting in increased tumor cell proliferation and poor survival …

Inflammation is an etiological factor of various chronic diseases contributing to more than
50% of worldwide deaths. In this study, we focus on the immunosuppressive role of the …

Chemotherapy upregulates immune checkpoint (IC) expression on the surface of tumour
cells and IC-intrinsic signalling confers a survival advantage against chemotherapy in …

Human leukocyte antigen class I (HLA-I) is considered a genetic pathogen for ulcerative
colitis (UC). This study aimed to investigate the significance of DNA damage and HLA-I …

Colitis ulcerosa (CU) ist eine chronisch-entzündliche Darmerkrankung, die meist im Rektum
beginnt, sich im Verlauf der Erkrankung kontinuierlich auf das gesamte Kolorektum …

Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of
the most common causes of death amongst the pediatric malignancies. There is however a …

Oesophagogastric junctional adenocarcinoma (OGJ) is an aggressive malignancy with a
high propensity to metastasise. Response rates to first-line chemo (radio) therapy regimens …