O-modi? ed ribosyl nucleosides and modi? ed oligonucle otides containing such
nucleotides are disclosed. Oligo nucleotides are disclosed that have increased binding …

2015-07-20 Assigned to MODERNA THERAPEUTICS, INC. reassignment MODERNA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

CYJHGLMKTOQCCE-IIYSOPAGSA-N CCCCCC/C= C/CC (C)(C) C. CCCCCC/C= C\CC
(C)(C) C Chemical compound CCCCCC/C= C/CC (C)(C) C. CCCCCC/C= C\CC (C)(C) C …

2016-03-17 Assigned to MODERNA THERAPEUTICS, INC. reassignment MODERNA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

5,359,044. A 10/1994 Cook et al.... 536/23.1 assays and in HIV-infected cells.” Proc. Natl.
Acad. Sci. 5,393,878 A 2/1995 Leumann......... 536/28.2 USA, 1995, 92, 9383-9387 …

Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or
more Sites on an oligonucle otide including the 2-, 3-, 5'-, nucleobase and internucle otide …

The present invention provides novel antisense oligonucleotides that target the genes and
mRNAs encoding mammalian Estrogen Receptors (ER) alpha and/or beta and modulate the …

the present disclosure provides a stabilized lipid nanoparticle (LNP) formulation comprising
a plurality of LNPs and a stabilizing agent that mitigates the degradation of the LNPs or a …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
45893552&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

We report a novel approach for the attachment of DNA fragments to the surface of live cells.
By using fluorescence microscopy and flow cytometry we demonstrated that our synthetic …