Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and
cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) …

Antidepressants refer to psychotropic drugs which are used to treat mental illness with
prominent emotional depression symptoms. It was reported that antidepressants had …

Bladder cancer is known as one of the top ten most common cancer types worldwide and
can be majorly divided into muscles invasive bladder cancer (MIBC) and non-muscles …

Background/Aim: Osteosarcoma is an aggressive primary malignant bone tumor that occurs
in childhood. Although the diagnostic and treatment options have been improved …

Simple Summary Tricyclic antidepressants (TCAs) are old and known therapeutic agents
whose good safety profile makes them good candidates for drug repurposing. As the …

Aberrant activities of various cell cycle and DNA repair proteins promote cancer growth and
progression and render them resistant to therapies. Here, we demonstrate that the anti …

Background Bladder cancer (BC) is a challenging disease to manage. Researchers have
been investigating the potential of magnolol, a compound derived from Magnolia officinalis …

Colorectal cancer (CRC) is recognized as the third most common malignancy and the
second most deadly in highly developed countries. Although the treatment of CRC has …

Simple Summary Protein kinase C (PKC) isozymes play key roles in the proliferation,
differentiation, survival, migration, invasion, apoptosis, and anticancer drug resistance of …

Background/Aim: Hepatocellular carcinoma (HCC) is a primary liver cancer with limited
treatment options and poor prognosis. Regorafenib, a multi-kinase inhibitor, has shown …