Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies

DR Skvarc, M Berk, LK Byrne, OM Dean, S Dodd… - Neuroscience & …, 2018 - Elsevier
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

Should general anaesthesia be avoided in the elderly?

C Strøm, LS Rasmussen, FE Sieber - Anaesthesia, 2014 - Wiley Online Library
Surgery and anaesthesia exert comparatively greater adverse effects on the elderly than on
the younger brain, manifest by the higher prevalence of postoperative delirium and cognitive …

[HTML][HTML] Optimised anaesthesia to reduce post operative cognitive decline (POCD) in older patients undergoing elective surgery, a randomised controlled trial

C Ballard, E Jones, N Gauge, D Aarsland, OB Nilsen… - PloS one, 2012 - journals.plos.org
Background The study determined the one year incidence of post operative cognitive
decline (POCD) and evaluated the effectiveness of an intra-operative anaesthetic …

[HTML][HTML] Role of peripheral inflammatory markers in postoperative cognitive dysfunction (POCD): a meta-analysis

L Peng, L Xu, W Ouyang - PloS one, 2013 - journals.plos.org
Background Postoperative cognitive dysfunction (POCD) is common following cardiac and
non-cardiac surgery, but the pathogenic mechanisms remain unknown. Many studies …

[HTML][HTML] Postoperative cognitive dysfunction after inhalational anesthesia in elderly patients undergoing major surgery: the influence of anesthetic technique, cerebral …

Y Qiao, H Feng, T Zhao, H Yan, H Zhang, X Zhao - BMC anesthesiology, 2015 - Springer
Background Elderly patients are reportedly at higher risk of postoperative cognitive
dysfunction (POCD) after inhalational anesthesia with sevoflurane. We hypothesized that the …

Postoperative cognitive dysfunction after cardiac surgery

L Gao, R Taha, D Gauvin, LB Othmen, Y Wang… - Chest, 2005 - Elsevier
Prolonged postoperative cognitive dysfunction (POCD) is reported to occur frequently after
cardiac surgery. However, it is rarely assessed in routine clinical practice and receives little …

[PDF][PDF] Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly

D Rohan, DJ Buggy, S Crowley, FKH Ling… - Canadian Journal of …, 2005 - researchgate.net
Purpose: Postoperative cognitive dysfunction (POCD) is evident in 26% of elderly patients
seven days after major non-cardiac surgery. Despite the growing popularity of day surgery …

Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury

DL McDonagh, JP Mathew, WD White… - The Journal of the …, 2010 - pubs.asahq.org
Background Postoperative cognitive dysfunction (POCD) is a significant cause of morbidity
after noncardiac surgery. Identified risk factors are largely limited to demographic …

Effect of subanesthetic dose of esketamine on perioperative neurocognitive disorders in elderly undergoing gastrointestinal surgery: a randomized controlled trial

C Han, H Ji, Y Guo, Y Fei, C Wang, Y Yuan… - Drug Design …, 2023 - Taylor & Francis
Background Perioperative neurocognitive disorders (PND), including delayed
neurocognitive recovery (dNCR) and postoperative cognitive dysfunction (POCD), are …

Perioperative inflammatory response and protein S‐100β concentrations–relationship with post‐operative cognitive dysfunction in elderly patients

YC Li, CH Xi, YF An, WH Dong… - Acta Anaesthesiologica …, 2012 - Wiley Online Library
Background One major concern in about one third of elder patients after total hip‐
replacement surgery is post‐operative cognitive dysfunction (POCD). Previous studies have …