Specialized receptors belonging to the transient receptor potential (TRP) family of ligand-
gated ion channels constitute the critical detectors and transducers of pain-causing stimuli …

Pain is an ubiquitous symptom in osteoarticular diseases, occurring much more commonly
than stiffness or disability. OA of the knee, hand, or hip affects around 20% of adults in …

Capsaicin is the pungent ingredient of chili peppers and is approved as a topical treatment
of neuropathic pain. The analgesia lasts for several months after a single treatment …

Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca2+ permeable cation
channel activated by noxious heat, and chemical ligands, such as capsaicin and …

Objective While the prevalence of radiographic and symptomatic osteoarthritis (OA) is higher
in women, male mice are more frequently used in animal experiments to explore its …

Arthritis is the commonest cause of disabling chronic pain, and both osteoarthritis (OA) and
rheumatoid arthritis (RA) remain major burdens on both individuals and society. Peripheral …

Pharmacomodulation of membrane channels is an essential topic in the study of
physiological conditions and disease status. Transient receptor potential (TRP) channels are …

The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary
somatosensory neurons termed nociceptors. The molecular receptors of noxious …

Aging is a risk factor for the development of osteoarthritis (OA), a progressive joint disease
leading to cartilage damage, pain, and loss of function. In a mouse model of OA, senolytic …

Objective: A pre/post pilot study was designed to investigate neurobiological mechanisms
and plasma metabolites in an 8-week Tai-Chi (TC) group intervention in subjects with knee …