Pain is the most frequent symptom of osteoarthritis (OA), occurring much more commonly
than stiffness or disability. Classically, OA-related pain has been considered to be a …

Background This study was performed to develop therapeutic targets of osteoarthritis (OA)
that can be targeted to alleviate OA development (ie, cartilage destruction) and relieve the …

Background Metformin could activate adenosine monophosphate-activated protein kinase
(AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study …

Hyaluronan (HA) is present in the extracellular matrix of all body tissues, including synovial
fluid in joints, in which it behaves as a filter that buffers transmission of mechanical forces to …

Vascular endothelial growth factor-A (VEGF-A) is best known as a key regulator of the
formation of new blood vessels. Neutralization of VEGF-A with anti-VEGF therapy eg …

Osteoarthritis (OA) is a chronic joint disease that represents an increasingly substantial
global burden. Joint pain is the most significant symptom of OA. Unfortunately, current …

The lungs are essential for gas exchange and serve as the gateways of our body to the
external environment. They are easily accessible for drugs from both sides, the airways and …

This study aims to determine the molecular mechanisms and analgesic effects of transient
receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid …

Capsaicin is a potent agonist of the TRPV1 channel, a transduction channel that is highly
expressed in nociceptive fibers (pain fibers) throughout the peripheral nervous system …

Bioactives significantly modify and maintain human health. Available data suggest that
Bioactives might play a beneficial role in chronic inflammatory diseases. Although promised …