Worldwide, osteoarthritis (OA) is one of the leading causes of chronic pain, for which
adequate relief is not available. Ongoing peripheral input from the affected joint is a major …

Simple Summary Increasing societal and customer pressure to provide animals with 'a life
worth living'continues to apply pressure on industry to alleviate pain associated with …

Objective Links between pain and joint degradation are poorly understood. We investigated
the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and …

Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Ca2+
permeable, non-selective cation channel that is found primarily in sensory nerve fibres …

Osteoarthritis (OA) is a degenerative joint disease manifested by movement limitations and
chronic pain. Endocannabinoid system (ECS) may modulate nociception via cannabinoid …

Objective To assess the functional changes of Transient receptor potential vanilloid 1
(TRPV1) receptor and to clarify its mechanism in a rat mono-iodoacetate (MIA)-induced joint …

Introduction: Osteoarthritis (OA) is a prevalent joint disorder worldwide. Sodium hyaluronate
(SH) and mesenchymal stem cells (MSCs) are promising therapeutic strategies for OA …

Objective The present study aimed to elucidate the mechanisms involved in MSU-induced IL-
1β release in a rodent animal model of acute gout arthritis. Methods Painful (mechanical and …

Transient receptor potential channels (TRP channels) are cation selective transmembrane
receptors with diverse structures, activation mechanisms and physiological functions. TRP …

Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of
significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain …