Introduction: Osteoarthritis (OA) is a prevalent joint disorder worldwide. Sodium hyaluronate
(SH) and mesenchymal stem cells (MSCs) are promising therapeutic strategies for OA …

Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of
significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain …

Systems pharmacology employs computational and mathematical methods to study the
network of interactions a drug may have within complex biological pathways. These tools …

Transient receptor potential vanilloid 4 (TRPV4) receptor modulates pain, and this has been
noted in several animal models. However, the involvement of TRPV4 in osteoarthritic (OA) …

Voltage-gated sodium channel blockers are not traditionally recommended for osteoarthritis
(OA) pain therapy, but given the large peripheral drive that follows OA development there is …

Aims The daily activity of osteoarthritis (OA) patients is limited by chronic pain and central
sensitization. Although non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen …

Osteoarthritis (OA) is a joint disease in which cartilage degenerates as a result of
mechanical and biochemical changes. The main OA symptom is chronic pain involving both …

Objective This commentary aims to summarise the importance of the joint nervous system in
maintaining joint homeostasis and the role of nerves in contributing to degenerative …

Abstract Ethnopharmacological relevance The genus Rhodiola has been used to treat
cough, hemoptysis, fever, pain, bruise and other symptoms which are related to injury and …

The transient receptor potential channel vanilloid type 1 (TRPV1) is a non-selective cation
channel expressed in sensory neurons of the dorsal root and trigeminal ganglia. TRPV1 is a …