This study investigated the perioperative effects of preemptive intra-articular lidocaine (L
group), dexmedetomidine (D group) and lidocaine-dexmedetomidine (LD group) in dogs …

Capsaicin administration induces pain through effects mediated by activation of the TRPV1
channel. However, depending on dose, capsaicin also reversibly ablates nociceptors …

Objective Synovitis is a widely accepted sign of osteoarthritis (OA), characterised by tissue
hyperplasia, where increased infiltration of immune cells and proliferation of resident …

The function of δ opioid receptors (DOR) expressed by peripheral pain-sensing neurons
(nociceptors) is regulated by both cyclooxygenase-and lipoxygenase (LOX)-dependent …

Radiating pain is a significant feature of chronic musculoskeletal pain conditions such as
radiculopathies, repetitive motion disorders and whiplash associated disorders. It is reported …

Increasing societal and customer pressure to provide animals with 'a life worth
living'continues to apply pressure on livestock production industries to alleviate pain …

Hyaluronan (sodium hyaluronate, HA) is a very long, anionic linear polymer ubiquitously
present in the extracellular matrix (ECM) of mammals, where it forms loose and elastic …

Osteoarthritis (OA) is a debilitating joint disorder affecting more than 240 million people.
There is no disease modifying therapeutic, and drugs that are used to alleviate OA …

Pain is a common presenting and often persistent symptom for children with rheumatological
disease. Pain is not clearly related to disease severity in children with inflammatory juvenile …

Identification of new targets will inform and guide future research, aiding the development of
more effective analgesics. Future clinical trial designs should implement sensory …