Disrupting KATP channels diminishes the estrogen-mediated protection in female mutant mice during ischemia-reperfusion
Background Estrogen has been shown to mediate protection in female hearts against
ischemia-reperfusion (IR) stress. Composed by a Kir6. 2 pore and an SUR2 regulatory …
ischemia-reperfusion (IR) stress. Composed by a Kir6. 2 pore and an SUR2 regulatory …
[HTML][HTML] Effect of visfatin on KATP channel upregulation in colonic smooth muscle cells in diabetic colon dysmotility
T Yu, L Zhang, Y Wang, X Shen, L Lin, Y Tang - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
The mechanisms of diabetes-related gastrointestinal dysmotility remains unclear. This study
aimed to investigate the effect and mechanisms of proinflammatory adipokine visfatin (VF) in …
aimed to investigate the effect and mechanisms of proinflammatory adipokine visfatin (VF) in …
[HTML][HTML] Abcc9 is required for the transition to oxidative metabolism in the newborn heart
JP Fahrenbach, D Stoller, G Kim, N Aggarwal… - The FASEB …, 2014 - ncbi.nlm.nih.gov
The newborn heart adapts to postnatal life by shifting from a fetal glycolytic metabolism to a
mitochondrial oxidative metabolism. Abcc9, an ATP-binding cassette family member …
mitochondrial oxidative metabolism. Abcc9, an ATP-binding cassette family member …
ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant
NT Aggarwal, NQ Shi, JC Makielski - Channels, 2013 - Taylor & Francis
Cardiac ATP-sensitive potassium channels (KATP) are found in both the sarcoplasmic
reticulum (sarcKATP) and the inner membrane of mitochondria (mitoKATP). SarcKATP are …
reticulum (sarcKATP) and the inner membrane of mitochondria (mitoKATP). SarcKATP are …
Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle
E Kefaloyianni, L Bao, MJ Rindler, M Hong… - Journal of Molecular and …, 2012 - Elsevier
Since ion channels move electrical charge during their activity, they have traditionally been
studied using electrophysiological approaches. This was sometimes combined with …
studied using electrophysiological approaches. This was sometimes combined with …
Differential roles for SUR subunits in KATP channel membrane targeting and regulation
Since their discovery over 25 years ago, KATP channels have been studied extensively in
many 33 tissues, including heart, pancreas, brain, skeletal and smooth muscle, pituitary and …
many 33 tissues, including heart, pancreas, brain, skeletal and smooth muscle, pituitary and …
[HTML][HTML] Cardiac overexpression of a mitochondrial SUR2A splice variant impairs cardiac function and worsens myocardial ischemia reperfusion injury in female mice
AC Wexler, H Dooge, S El-Meanawy, E Santos… - Journal of Molecular and …, 2024 - Elsevier
The small splice variant of the sulfonylurea receptor protein isoform 2 A (SUR2A-55) targets
mitochondria and enhances mitoK ATP activity. In male mice the overexpression of this …
mitochondria and enhances mitoK ATP activity. In male mice the overexpression of this …
SURA2 targeting for cardioprotection?
A Jovanović, S Jovanović - Current opinion in pharmacology, 2009 - Elsevier
SUR2A is an ATP-binding protein known to serve as a regulatory subunit of metabolic-
sensing, cardioprotective sarcolemmal ATP-sensitive K+ (KATP) channels. It has been …
sensing, cardioprotective sarcolemmal ATP-sensitive K+ (KATP) channels. It has been …
Impaired exercise tolerance and skeletal muscle myopathy in sulfonylurea receptor-2 mutant mice
D Stoller, P Pytel, S Katz, JU Earley… - American Journal …, 2009 - journals.physiology.org
By sensing intracellular energy levels, ATP-sensitive potassium (KATP) channels help
regulate vascular tone, glucose metabolism, and cardioprotection. SUR2 mutant mice lack …
regulate vascular tone, glucose metabolism, and cardioprotection. SUR2 mutant mice lack …