Conspectus The aberrant misfolding and aggregation of peptides and proteins into amyloid
aggregates occurs in over 50 largely incurable protein misfolding diseases. These …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

Most of the cell's chemical reactions and structural components are facilitated by proteins.
But proteins are highly dynamic molecules, where numerous modifications or changes in the …

Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

The β-sheet–rich amyloid core is the defining feature of protein aggregates associated with
neurodegenerative disorders. Recent investigations have revealed that there exist multiple …

Natural aminosterols are promising drug candidates against neurodegenerative diseases,
like Alzheimer and Parkinson, and one relevant protective mechanism occurs via their …

Parkinson's disease is characterised by the presence in brain tissue of aberrant inclusions
known as Lewy bodies and Lewy neurites, which are deposits composed by α-synuclein …

Amyloidosis is a term referring to a group of various protein-misfolding diseases wherein
normally soluble proteins form aggregates as insoluble amyloid fibrils. How, or whether …