The filoviruses (Marburg and Ebola) are perhaps the most mysterious of the viral agents that
afflict humans. They emerge unpredictably in central Africa to cause epidemics of severe …

Ebola virus is a highly lethal pathogen that causes hemorrhagic fever in humans and
nonhuman primates. Among the seven known viral gene products, the envelope …

The recent Ebola epidemics in West Africa underscore the great need for effective and
practical therapies for future Ebola virus outbreaks. We have discovered a new series of …

Despite intensive research and considerable effort to eradicate infectious diseases, modern
medicine has failed to control many infectious diseases which have been thought to be easy …

Viral hemorrhagic fever (VHF) is an acute febrile syndrome characterized by systemic
involvement, which includes generalized bleeding in severe infections. Patients with VHF …

Enveloped viruses often require cleavage of a surface glycoprotein by a cellular
endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola …

Ebola virus (EBOV) causes hemorrhagic fever in humans and nonhuman primates with up to
90% mortality rate. In this study, Ebola virus like particles (EVLPs) and the aglycosyl …

Ebola virus causes an acute hemorrhagic fever that is associated with high morbidity and
mortality. The viral glycoprotein is thought to contribute to pathogenesis, though precise …

13F6-1-2 is a murine monoclonal antibody that recognizes the heavily glycosylated mucin-
like domain of the Ebola virus virion-attached glycoprotein (GP) and protects animals …