Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Double‐stranded (ds) RNA has diverse roles in gene expression and regulation, host
defense, and genome surveillance in bacterial and eukaryotic cells. A central aspect of …

RNA editing describes targeted sequence alterations in RNAs so that the transcript
sequences differ from their DNA template. Since the original discovery of RNA editing in …

RNA editing, which adds sequence information to RNAs post‐transcriptionally, is a
widespread phenomenon throughout eukaryotes. The most complex form of this process is …

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

The composition of the large, single, mitochondrion (mt) of Trypanosoma brucei was
characterized by MS (2‐D LC‐MS/MS and gel‐LC‐MS/MS) analyses. A total of 2897 …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …

Trypanosomatid RNA editing is a unique process and essential for these organisms. It
therefore represents a drug target for a group of protozoa that includes the causative agents …

In the mitochondria of trypanosomatids, the majority of mRNAs undergo massive uracil-
insertion/deletion editing. Throughout the processes of pre-mRNA polyadenylation, guide …