Engineered C–S bond construction

CF Lee, RS Basha, SS Badsara - Sulfur Chemistry, 2019 - Springer
Due to the versatile applications of thioethers and thioesters in organic synthesis, medicinal
chemistry, the pharmaceutical industry, and materials science, recently the construction of C …

Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii

WW Gao, L Gopala, RRY Bheemanaboina… - European journal of …, 2018 - Elsevier
Aminothiazolyl berberine derivatives as potentially antimicrobial agents were designed and
synthesized in an effort to overcome drug resistance. The antimicrobial assay revealed that …

Antibacterial activity of pharmaceutical-grade rose bengal: An application of a synthetic dye in antibacterial therapies

M Kurosu, K Mitachi, J Yang, EV Pershing, BD Horowitz… - Molecules, 2022 - mdpi.com
Rose bengal has been used in the diagnosis of ophthalmic disorders and liver function, and
has been studied for the treatment of solid tumor cancers. To date, the antibacterial activity of …

Discovery of a Potent Adenine–Benzyltriazolo–Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA

CV Heidtmann, F Voukia, LN Hansen… - Journal of Medicinal …, 2020 - ACS Publications
Conjugation of pleuromutilin is an attractive strategy for the development of novel antibiotics
and the fight against multiresistant bacteria as the class is associated with low rates of …

Novel Naphthalimide Nitroimidazoles as Multitargeting Antibacterial Agents against Resistant Acinetobacter Baumannii

J Kang, L Gopala, VK Reddy Tangadanchu… - Future Medicinal …, 2018 - Taylor & Francis
Aim: The increasing emergence of resistant bacteria imposed an urgent request to discover
novel antibacterial agents. This work was to develop naphthalimide nitroimidazoles as …

Discovery of urea-based pleuromutilin derivatives as potent gram-positive antibacterial agents

Z Wu, X Zhu, A Hong, G He, Z Wang, Q Xu, Z Hu… - Bioorganic …, 2023 - Elsevier
There is an urgent need to discover new antibacterial drugs and provide new treatment
options for clinical antimicrobial resistance (AMR) pathogen infections. Inspired by the …

Identification of a Family of Glycoside Derivatives Biologically Active against Acinetobacter baumannii and Other MDR Bacteria Using a QSPR Model

FJ Palacios-Can, J Silva-Sánchez, I León-Rivera… - Pharmaceuticals, 2023 - mdpi.com
As the rate of discovery of new antibacterial compounds for multidrug-resistant bacteria is
declining, there is an urge for the search for molecules that could revert this tendency …

Valnemulin restores colistin sensitivity against multidrug-resistant gram-negative pathogens

C Xu, Y Zhang, L Ma, G Zhang, C Li, C Zhang… - Communications …, 2024 - nature.com
Colistin is one of the last-resort antibiotics in treating infections caused by multidrug-resistant
(MDR) pathogens. Unfortunately, the emergence of colistin-resistant gram-negative strains …

Synergistic Effect of Pleuromutilins with Other Antimicrobial Agents against Staphylococcus aureus In Vitro and in an Experimental Galleria mellonella Model

CL Dong, LX Li, ZH Cui, SW Chen, YQ Xiong… - Frontiers in …, 2017 - frontiersin.org
Invasive infections due to Staphylococcus aureus, including methicillin-resistant S. aureus
are prevalent and life-threatening. Combinations of antibiotic therapy have been employed …

Palladium‐Catalyzed Decarbonylative Thioetherification of 2‐Pyridyl Thioesters

SF Wang, CE Li, YC Liu… - Asian Journal of …, 2020 - Wiley Online Library
An efficient palladium‐catalyzed intramolecular decarbonylative thioetherification of 2‐
pyridyl thioesters to furnish 2‐pyridyl aryl or alkyl thioethers is reported. Notably …