Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …

A wide variety of new medication disclosures launched by specific benefits of the general
public are laced with poor aqueous solubility problems that often obstruct their bioavailability …

Purpose The study discusses the value of electrospun cilostazol-loaded (CIL) polymer
structures for potential vascular implant applications. Methods Biodegradable …

Rivaroxaban (RXB) is an orally active direct inhibitor of the activated serine protease Factor
Xa, given as monotherapy in the treatment of venous thromboembolism (VTE). It has been …

Poorly water-soluble drugs belonging to BCS Class II and IV present a big challenge to
formulators owing to their limited solubility and bioavailability. Alectinib hydrochloride (ALB) …

In the present study, a lyophilized milk-based solid dispersion (SD) of ritonavir (RTV) was
developed with the goal of improving its aqueous solubility. The SD was prepared by …

The aim of the study was to formulate cilostazol containing nanosuspension by top-down
wet milling method in order to increase the in vitro solubility and dissolution rate of this …

Cilostazol (CLZ) acts as a vasodilator and antiplatelet agent and is the main drug for the
treatment of intermittent claudication (IC) related to peripheral arterial disease (PAD). The …

The pH–induced crystallization of weakly basic drugs in the small intestine limits oral
bioavailability. In this study, we investigated the solubilization and inhibitory effects on …

Drug delivery devices are attractive alternatives to drugs usually orally administrated.
Therefore, this work aimed to produce PLA/PBAT-based nanofibers for the controlled …