An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

U Hossain, AK Das, S Ghosh, PC Sil - Food and chemical toxicology, 2020 - Elsevier
Recently the use of bioactive α-glucosidase inhibitors for the treatment of diabetes have
been proven to be the most efficient remedy for controlling postprandial hyperglycemia and …

Recent updates on phytoconstituent alpha-glucosidase inhibitors: An approach towards the treatment of type two diabetes

H Kashtoh, KH Baek - Plants, 2022 - mdpi.com
Diabetes is a common metabolic disorder marked by unusually high plasma glucose levels,
which can lead to serious consequences such as retinopathy, diabetic neuropathy and …

[HTML][HTML] Novel insights into the pathogenesis and management of the metabolic syndrome

HH Wang, DK Lee, M Liu, P Portincasa… - … , hepatology & nutrition, 2020 - ncbi.nlm.nih.gov
The metabolic syndrome, by definition, is not a disease but is a clustering of individual
metabolic risk factors including abdominal obesity, hyperglycemia, hypertriglyceridemia …

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

ME Ertunc, GS Hotamisligil - Journal of lipid research, 2016 - ASBMB
Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act …

Inflammation of brown/beige adipose tissues in obesity and metabolic disease

F Villarroya, R Cereijo… - Journal of internal …, 2018 - Wiley Online Library
Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases,
are related to the low‐grade chronic inflammation of white adipose tissue. Under white …

Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature

N Muvhulawa, PV Dludla, K Ziqubu… - Pharmacological …, 2022 - Elsevier
Chronic inflammation remains an essential complication in the pathogenesis and
aggravation of metabolic diseases. There is a growing interest in the use of medicinal plants …

Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?

S Venn-Watson, R Lumpkin, EA Dennis - Scientific reports, 2020 - nature.com
Dietary odd-chain saturated fatty acids (OCFAs) are present in trace levels in dairy fat and
some fish and plants. Higher circulating concentrations of OCFAs, pentadecanoic acid (C15 …

Anti‐inflammatory Effects of Empagliflozin and Gemigliptin on LPS‐Stimulated Macrophage via the IKK/NF‐κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways

N Lee, YJ Heo, SE Choi, JY Jeon… - Journal of …, 2021 - Wiley Online Library
Background. Sodium‐glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase‐4 (DPP‐4)
inhibitors are glucose‐lowering drugs whose anti‐inflammatory properties have recently …

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

N Esser, S Legrand-Poels, J Piette, AJ Scheen… - Diabetes research and …, 2014 - Elsevier
It is recognized that a chronic low-grade inflammation and an activation of the immune
system are involved in the pathogenesis of obesity-related insulin resistance and type 2 …

Role of c-Jun N-terminal kinase (JNK) in obesity and type 2 diabetes

JHM Yung, A Giacca - Cells, 2020 - mdpi.com
Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …