Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

Abstract Seven-transmembrane receptors (7TMRs; also known as G protein-coupled
receptors) are the largest class of receptors in the human genome and are common targets …

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

Background & Aims Desmoplasia and poor vascularity cause severe metabolic stress in
pancreatic ductal adenocarcinomas (PDACs). Serotonin (5-HT) is a neuromodulator with …

Metabolic reprogramming is a malignant phenotype of cancer. Cancer cells utilize glycolysis
to fuel rapid proliferation even in the presence of oxygen, and elevated glycolysis is coupled …

ABSTRACT G-protein-coupled receptors (GPCRs) are the largest family of receptors in
many organisms, including worms, mice and humans. GPCRs are seven-transmembrane …

Cellular signal transmission requires the dynamic formation of spatiotemporally controlled
molecular interactions. At the cell surface information is received by receptor complexes and …

Abstract 2852 The polyphenolic phytoalexin resveratrol (RSV) and its analogues have
received tremendous attention over the past couple of decades because of a number of …

The effects of estrogen are widespread throughout the body. Although the classical nuclear
estrogen receptors have been known for many years to decades and their primary modes of …