Elevation of cAMP inhibits the proliferation and expression of transformed phenotype in
several cell types, including breast cancer cells. Leptin has been shown to act as a …

A long-standing question in the field of signal transduction is how distinct signaling
pathways interact with each other to control cell behavior. Growth factor receptors and G …

The G protein-coupled receptor P2Y 2 nucleotide receptor (P2Y 2 R) has been shown to be
up-regulated in a variety of tissues in response to stress or injury. Recent studies have …

Introduction: The ectodomain shedding of epidermal growth factor receptor (EGFR) ligands,
such as amphiregulin (AREG), by ADAMs (A Disintegrin And Metalloproteases) can be …

The most common sites of malignancies in the aerodigestive tract include the lung, head
and neck and the esophagus. Esophageal adenocarcinomas (EA), esophageal squamous …

Gliomas are the most common malignant intracranial tumors. Newly developed targeted
therapies for these cancers aim to inhibit oncogenic signals, many of which emanate from …

Controlling angiotensin AT 1 receptor function has been shown to be protective for many
pathophysiological disorders. Although estrogen metabolite, 2-methoxyestradiol (2ME2) can …

We analyzed the cross-talk between receptors for vasoactive intestinal peptide (VIP) and the
human epidermal growth factor family of tyrosine kinase receptors (HER) in oestrogen …

Angiotensin II (Ang II) is the product of the proteolytic action of angiotensin‐converting
enzyme (ACE) on the precursor peptide, angiotensin I (Ang I). In addition to its vasoactive …

Kinin peptides exert multiple biological effects by binding to two types of G protein-coupled
receptors known as B 1 (B 1 R) and B 2 receptors. Expression of the B 1 R in human breast …