Bioactive potential of natural biomaterials: Identification, retention and assessment of biological properties

K Joyce, GT Fabra, Y Bozkurt, A Pandit - Signal transduction and …, 2021 - nature.com
Biomaterials have had an increasingly important role in recent decades, in biomedical
device design and the development of tissue engineering solutions for cell delivery, drug …

A comprehensive review: sphingolipid metabolism and implications of disruption in sphingolipid homeostasis

BM Quinville, NM Deschenes, AE Ryckman… - International journal of …, 2021 - mdpi.com
Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

Membrane phase separation drives responsive assembly of receptor signaling domains

SA Shelby, I Castello-Serrano, KC Wisser… - Nature Chemical …, 2023 - nature.com
Plasma membrane heterogeneity has been tied to a litany of cellular functions and is often
explained by analogy to membrane phase separation; however, models based on phase …

The mystery of membrane organization: composition, regulation and roles of lipid rafts

E Sezgin, I Levental, S Mayor, C Eggeling - Nature reviews Molecular …, 2017 - nature.com
Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

Cholesterol-rich lipid rafts as platforms for SARS-CoV-2 entry

SN Palacios-Rápalo, LA De Jesus-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2),
the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Molecular targets of epigallocatechin—Gallate (EGCG): A special focus on signal transduction and cancer

A Negri, V Naponelli, F Rizzi, S Bettuzzi - Nutrients, 2018 - mdpi.com
Green tea is a beverage that is widely consumed worldwide and is believed to exert effects
on different diseases, including cancer. The major components of green tea are catechins, a …

Sphingolipids and lipid rafts: Novel concepts and methods of analysis

E Bieberich - Chemistry and physics of lipids, 2018 - Elsevier
About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid rafts

F Mollinedo, C Gajate - Journal of lipid research, 2020 - ASBMB
Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

[HTML][HTML] The role of high cholesterol in age-related COVID19 lethality.

H Wang, Z Yuan, MA Pavel, SM Jablonski, J Jablonski… - BioRxiv, 2020 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID19) is a respiratory infection caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in …