Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1
(PD-1)/programmed cell death-ligand 1 (PD-L1) are two most representative immune …
(PD-1)/programmed cell death-ligand 1 (PD-L1) are two most representative immune …
Regulation of PD-L1 expression in the tumor microenvironment
M Yi, M Niu, L Xu, S Luo, K Wu - Journal of hematology & oncology, 2021 - Springer
Abstract Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …
Regulation and function of the PD-L1 checkpoint
Expression of programmed death-ligand 1 (PD-L1) is frequently observed in human
cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor …
cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor …
Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond
L Ai, A Xu, J Xu - Regulation of Cancer Immune Checkpoints: Molecular …, 2020 - Springer
Immunotherapies that target PD-1/PD-L1 axis have shown unprecedented success in a wide
variety of human cancers. PD-1 is one of the key coinhibitory receptors expressed on T cells …
variety of human cancers. PD-1 is one of the key coinhibitory receptors expressed on T cells …
The diverse function of PD-1/PD-L pathway beyond cancer
The recent success of PD-1 and PD-L1 blockade in cancer therapy illustrates the important
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
X Jiang, J Wang, X Deng, F Xiong, J Ge, B Xiang, X Wu… - Molecular cancer, 2019 - Springer
Tumor immune escape is an important strategy of tumor survival. There are many
mechanisms of tumor immune escape, including immunosuppression, which has become a …
mechanisms of tumor immune escape, including immunosuppression, which has become a …
Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade
SJ Dovedi, AL Adlard, G Lipowska-Bhalla, C McKenna… - Cancer research, 2014 - AACR
Radiotherapy is a major part in the treatment of most common cancers, but many patients
experience local recurrence with metastatic disease. In evaluating response biomarkers, we …
experience local recurrence with metastatic disease. In evaluating response biomarkers, we …
The PD-1/PD-Ls pathway and autoimmune diseases
S Dai, R Jia, X Zhang, Q Fang, L Huang - Cellular immunology, 2014 - Elsevier
Abstract The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, is a new member of
the B7/CD28 family, and consists of the PD-1 receptor and its ligands PD-L1 (B7-H1 …
the B7/CD28 family, and consists of the PD-1 receptor and its ligands PD-L1 (B7-H1 …
The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200
ABSTRACT PD-L1 expression and regulation by mesenchymal tumor cells remain largely
undefined. Here, we report that among different EMT-activated MCF7 human breast cancer …
undefined. Here, we report that among different EMT-activated MCF7 human breast cancer …
Duality of interactions between TGF-β and TNF-α during tumor formation
Z Liu, Y Zhang, L Zhang, T Zhou, Y Li, G Zhou… - Frontiers in …, 2022 - frontiersin.org
The tumor microenvironment is essential for the formation and development of tumors.
Cytokines in the microenvironment may affect the growth, metastasis and prognosis of …
Cytokines in the microenvironment may affect the growth, metastasis and prognosis of …