Chemokines are proteins which induce chemotaxis, promote differentiation of immune cells,
and cause tissue extravasation. Given these properties, their role in anti-tumor immune …

CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …

Metastatic colonization relies on interactions between disseminated cancer cells and the
microenvironment in secondary organs. Here, we show that disseminated breast cancer …

Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …

Chemokines and their receptors play a key role in development and homeostasis as well as
in the pathogenesis of tumors and autoimmune diseases. Chemokines are involved in the …

Metastasis still represents the primary cause of cancer morbidity and mortality worldwide.
Chemokine signalling contributes to the overall process of cancer growth and metastasis …

ABSTRACT Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many
cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic …

Chemokines are a key component of cancer-related inflammation. Chemokines and
chemokine receptors are downstream of genetic events that cause neoplastic transformation …

Metastasis involves critical interactions between cancer and stromal cells. Intratumoral
hypoxia promotes metastasis through activation of hypoxia-inducible factors (HIFs). We …