The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

The intent of this review is to describe what is known and unknown about telomerase in
somatic cells of the human organism. First, we consider the telomerase enzyme. Human …

Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA
and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP …

In yeast, telomere position effect (TPE) results in the reversible silencing of genes near
telomeres. Here we demonstrate the presence of TPE in human cells. HeLa clones …

Telomerase, a ribonucleoprotein acting as a reverse transcriptase, has been identified as a
target for cancer drug discovery. The synthetic, non-nucleosidic compound, BIBR1532, is a …

The extremities of eukaryotic chromosomes are called telomeres. They have a structure
unlike the bulk of the chromosome, which allows the cell DNA repair machinery to …

Chromosome stability requires a dynamic balance of DNA loss and gain in each terminal
tract of telomeric repeats. Repeat addition by a specialized reverse transcriptase …

The identities and roles of proteins associated with human telomerase remain poorly
defined. To gain insight, we undertook an affinity purification of endogenously assembled …

Ectopic expression of telomerase in telomerase-silent cells is sufficient to overcome
senescence and to extend cellular lifespan. We show here that the catalytic subunit of …

Telomeres are transcribed from the telomeric C-rich strand, giving rise to UUAGGG repeat-
containing telomeric transcripts or TERRA, which are novel structural components of …