Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …

Rationale: Doxorubicin is one of the most potent antitumor agents available; however, its
clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has …

The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture
experiments by allowing a better mimicry of human physiology and pathophysiology that has …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a
human-relevant platform for cardiac function assessment. Alternative assays using hiPSC …

The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …

Although cardiovascular toxicity from traditional chemotherapies has been well recognized
for decades, the recent explosion of effective novel targeted cancer therapies with …

Aims Regular exercise training benefits cardiovascular health and effectively reduces the
risk for cardiovascular disease. Circular RNAs (circRNAs) play important roles in cardiac …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), is considered as the most significant global public …