The synaptic plasticity and memory hypothesis asserts that activity-dependent synaptic
plasticity is induced at appropriate synapses during memory formation and is both …

Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are
highly enriched in synapses and are responsible for organizing the numerous protein …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

Synapses are found in vast numbers in the brain and contain complex proteomes. We
developed genetic labeling and imaging methods to examine synaptic proteins in individual …

Astrocytes are glial cells specific to the central nervous system and involved in numerous
brain functions, including regulation of synaptic transmission and of immune reactions …

Neuroplasticity is not only shaped by learning and memory but is also a mediator of
responses to neuron attrition and injury (compensatory plasticity). As an ongoing process it …

Excitatory synaptic transmission is largely mediated by AMPA receptors (AMPARs) present
at the postsynaptic density. Recent studies in single molecule tracking of AMPAR has …

IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to
humans. The most extensively studied family member is the ubiquitously expressed scaffold …

Background Sinisan (SNS) consists of four kinds of herbs, which is the core of
antidepressant prescription widely used in traditional Chinese medicine clinic treatment for …

Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …