Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated
from the Mavolanate-Shikimate biosynthesis pathways in plants. Several simple phenolic …

The peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α) is a
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …

Short-chain fatty acids (SCFAs) are the main products of dietary fiber fermentation and are
believed to drive the fiber-related prevention of the metabolic syndrome. Here we show that …

Endothelial dysfunction comprises a number of functional alterations in the vascular
endothelium that are associated with diabetes and cardiovascular disease, including …

Bone marrow adipogenesis is a normal physiologic process in all mammals. However, its
function is unknown. The mesenchymal stem cell is the marrow precursor for adipocytes as …

Peroxisome proliferator-activated receptors (PPARs) are transcription factors involved in the
regulation of numerous metabolic processes. The PPARα isotype is abundant in liver and …

Poly (ADP-ribosyl) ation (PARylation) is an essential post-translational modification
catalyzed by poly (ADP-ribose) polymerase (PARP) enzymes. Poly (ADP-ribose) …

Given worldwide increases in the incidence of obesity and type 2 diabetes, new strategies
for preventing and treating metabolic diseases are needed. The nuclear receptor PPARγ …

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ
to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these …

As the incidence of obesity is reaching 'epidemic'proportions, there is currently widespread
interest in the impact of dietary components on body-weight and food intake regulation. The …