Ursolic acid (UA) is a natural pentacyclic triterpenoid compound existing in various
traditional Chinese medicinal herbs, and it possesses diverse pharmacological actions and …

Skeletal muscle atrophy proceeds through a complex molecular signaling network that is
just beginning to be understood. Here, we discuss examples of recently identified molecular …

Th17 cells have recently emerged as a major player in inflammatory and autoimmune
diseases via the production of pro-inflammatory cytokines IL-17, IL-17F, and IL-22. The …

Current multiple sclerosis (MS) medications are mainly immunomodulatory, having little or
no effect on neuroregeneration of damaged central nervous system (CNS) tissue; they are …

Neuroinflammatory responses induced by amyloid-beta peptide (Aβ) are important causes
in the pathogenesis of Alzheimer's disease (AD). Blockade of Aβ has emerged as a possible …

Nuclear receptors (NRs) form a family of druggable transcription factors that are regulated by
ligand binding to orchestrate multifaceted physiological functions, including reproduction …

High altitude exposure leads to compromised physical performance with considerable
weight loss. The major stressor at high altitude is hypobaric hypoxia which leads to …

In addition to the known antitumour effects of ursolic acid (UA), increasing evidence
indicates that this molecule plays a role in cardiac protection. In this study, the effects of …

Background Activators of PPARs, particularly PPARγ, may be effective neuroprotective
drugs against inflammatory responses in cerebral ischemia and reperfusion injury. Ursolic …

Abstract Background Factor Xa inhibitor is used for preventing venous thromboembolism
(VTE) in adult patients receiving orthopedic operation. However, the role of factor Xa …