Coronary artery calcification and its progression: what does it really mean?

H Mori, S Torii, M Kutyna, A Sakamoto, AV Finn… - JACC: Cardiovascular …, 2018 - jacc.org
Coronary artery calcification is concomitant with the development of advanced
atherosclerosis. Coronary artery calcification pathologically begins as microcalcifications …

Pathology of human coronary and carotid artery atherosclerosis and vascular calcification in diabetes mellitus

K Yahagi, FD Kolodgie, C Lutter, H Mori… - … , and vascular biology, 2017 - Am Heart Assoc
The continuing increase in the prevalence of diabetes mellitus in the general population is
predicted to result in a higher incidence of cardiovascular disease. Although the …

TGF-β-induced endothelial to mesenchymal transition in disease and tissue engineering

J Ma, G Sanchez-Duffhues, MJ Goumans… - Frontiers in cell and …, 2020 - frontiersin.org
Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …

Arterial ageing: from endothelial dysfunction to vascular calcification

M Tesauro, A Mauriello, V Rovella… - Journal of internal …, 2017 - Wiley Online Library
Complex structural and functional changes occur in the arterial system with advancing age.
The aged artery is characterized by changes in micro RNA expression patterns, autophagy …

Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state

JI Borissoff, IA Joosen, MO Versteylen… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Aberrant neutrophil activation occurs during the advanced stages of
atherosclerosis. Once primed, neutrophils can undergo apoptosis or release neutrophil …

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization

LJ Schurgers, J Uitto, CP Reutelingsperger - Trends in molecular medicine, 2013 - cell.com
Vascular mineralization has recently emerged as a risk factor for cardiovascular morbidity
and mortality. Previously regarded as a passive end-stage process, vascular mineralization …

Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

M Kavousi, MM Bos, HJ Barnes, CL Lino Cardenas… - Nature …, 2023 - nature.com
Coronary artery calcification (CAC), a measure of subclinical atherosclerosis, predicts future
symptomatic coronary artery disease (CAD). Identifying genetic risk factors for CAC may …

Targeted delivery to bone and mineral deposits using bisphosphonate ligands

LE Cole, T Vargo-Gogola, RK Roeder - Advanced drug delivery reviews, 2016 - Elsevier
The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Endothelial‐to‐mesenchymal transition in cardiovascular diseases: developmental signaling pathways gone awry

G Sánchez‐Duffhues… - Developmental …, 2018 - Wiley Online Library
The process named endothelial‐to‐mesenchymal transition (EndMT) was observed for the
first time during the development of the chicken embryo several decades ago. Of interest …

Melatonin as an anti-aging therapy for age-related cardiovascular and neurodegenerative diseases

VM Martín Giménez, N de Las Heras… - Frontiers in Aging …, 2022 - frontiersin.org
The concept of “aging” is defined as the set of gradual and progressive changes in an
organism that leads to an increased risk of weakness, disease, and death. This process may …