Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

The critical roles of m6A RNA methylation in lung cancer: from mechanism to prognosis and therapy

MN Diao, XJ Zhang, YF Zhang - British Journal of Cancer, 2023 - nature.com
Lung cancer, a highly malignant disease, greatly affects patients' quality of life. N6-
methyladenosine (m6A) is one of the most common posttranscriptional modifications of …

[HTML][HTML] KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/MAPK pathway in an m6A-dependent manner

X Lin, R Ye, Z Li, B Zhang, Y Huang, J Du… - Drug Resistance …, 2023 - Elsevier
Non-small cell lung cancer is the leading cause of cancer related mortality worldwide, and
lung adenocarcinoma (LUAD) is one of the most common subtypes. The role of N6 …

Novel insights into mutual regulation between N6-methyladenosine modification and LncRNAs in tumors

N Zhang, Y Sun, Z Mei, Z He, S Gu - Cancer Cell International, 2023 - Springer
Abstract N6-methyladenosine (m6A), one of the most common RNA methylation
modifications, has emerged in recent years as a new layer of the regulatory mechanism …

[HTML][HTML] Novel insights into the interplay between m6A modification and programmed cell death in cancer

J Chen, M Ye, J Bai, C Hu, F Lu, D Gu… - International journal of …, 2023 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m6A) methylation, the most prevalent and abundant RNA
modification in eukaryotes, has recently become a hot research topic. Several studies have …

Emerging roles of m6A RNA modification in cancer therapeutic resistance

WW Liu, ZY Zhang, F Wang, H Wang - Experimental Hematology & …, 2023 - Springer
Marvelous advancements have been made in cancer therapies to improve clinical outcomes
over the years. However, therapeutic resistance has always been a major difficulty in cancer …

New insights into the interaction between m6A modification and lncRNA in cancer drug resistance

Y Jin, Z Fan - Cell Proliferation, 2024 - Wiley Online Library
Drug resistance is perhaps the greatest obstacle in improving outcomes for cancer patients,
leading to recurrence, progression and metastasis of various cancers. Exploring the …

[HTML][HTML] SNHG15 promotes chemoresistance and glycolysis in colorectal cancer

M Li, S Sun, Z Bian, S Yao, M Liu, X You - Pathology-Research and …, 2023 - Elsevier
Long noncoding RNAs (lncRNAs) play an important role in tumor progression. Small
nucleolar RNA host gene 15 (SNHG15) is a lncRNA that has been confirmed to play an …

METTL3 mediated MALAT1 m6A modification promotes proliferation and metastasis in osteosarcoma cells

Y Zhang, Y Xu, G Qiu, Y Luo, Y Bao, J Lu, T Wang… - Molecular …, 2023 - Springer
Background As one of the most ubiquitous types of posttranscriptional modification, N6-
methyladenosine (m6A) is extensively implicated in almost all types of cancers, including …

New insights into the regulation of METTL3 and its role in tumors

Q Jin, H Qu, C Quan - Cell Communication and Signaling, 2023 - Springer
As one of the most abundant epigenetic modifications in RNA, N6-methyladenosine (m6A)
affects RNA transcription, splicing, stability, and posttranscriptional translation …