[HTML][HTML] Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?
Tumor-infiltrating lymphocytes (TILs), frontline soldiers of the adaptive immune system, are
recruited into the tumor site to fight against tumors. However, their small number and …
recruited into the tumor site to fight against tumors. However, their small number and …
Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases
Abstract Cell secreted exosomes (30–100 nm vesicles) play a major role in intercellular
communication due to their ability to transfer proteins and nucleic acids from one cell to …
communication due to their ability to transfer proteins and nucleic acids from one cell to …
[HTML][HTML] Upregulation of PD-L1 by EGFR activation mediates the immune escape in EGFR-driven NSCLC: implication for optional immune targeted therapy for NSCLC …
Introduction Epidermal growth factor receptor (EGFR) mutation status was reported to be
associated with programmed death-ligand 1 (PD-L1) expression. However, the molecular …
associated with programmed death-ligand 1 (PD-L1) expression. However, the molecular …
[HTML][HTML] The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer
N Zhang, Y Zeng, W Du, J Zhu… - International …, 2016 - spandidos-publications.com
Negative regulation of the signal mediated by the programmed cell death protein 1 (PD-
1)/programmed death-ligand 1 (PD-L1) pathway can effectively inhibit the function of T and …
1)/programmed death-ligand 1 (PD-L1) pathway can effectively inhibit the function of T and …
PD-L1 expression is a favorable prognostic factor in early stage non-small cell carcinoma
Objectives Immune checkpoint blockade using inhibitors of programmed death-1 have
shown promise in early phase clinical trials in NSCLC and programmed death-ligand 1 (PD …
shown promise in early phase clinical trials in NSCLC and programmed death-ligand 1 (PD …
[HTML][HTML] Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: significance in claudin-low breast cancer cells
A Alsuliman, D Colak, O Al-Harazi, H Fitwi, A Tulbah… - Molecular cancer, 2015 - Springer
Background The T-cell inhibitory molecule PD-L1 (B7-H1, CD274) is expressed on tumor
cells of a subset of breast cancer patients. However, the mechanism that regulates PD-L1 …
cells of a subset of breast cancer patients. However, the mechanism that regulates PD-L1 …
[HTML][HTML] Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer
J Sheng, W Fang, J Yu, N Chen, J Zhan, Y Ma… - Scientific reports, 2016 - nature.com
The effects of treatments to programmed death ligand-1 (PD-L1) expression is unknown.
The aim of this study was to investigate the impact of neoadjuvant chemotherapy (NACT) on …
The aim of this study was to investigate the impact of neoadjuvant chemotherapy (NACT) on …
[HTML][HTML] The role of PD-L1 in the radiation response and clinical outcome for bladder cancer
CT Wu, WC Chen, YH Chang, WY Lin, MF Chen - Scientific reports, 2016 - nature.com
Identification of potential factors that can stratify a tumor's response to specific therapies will
aid in the selection of cancer therapy. The aim was to highlight the role of programmed cell …
aid in the selection of cancer therapy. The aim was to highlight the role of programmed cell …
[HTML][HTML] PD-L1 confers glioblastoma multiforme malignancy via Ras binding and Ras/Erk/EMT activation
XY Qiu, DX Hu, WQ Chen, RQ Chen, SR Qian… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor due to the lack of
effective therapeutic drugs. Cancer therapy targeting programmed cell death protein 1 (PD …
effective therapeutic drugs. Cancer therapy targeting programmed cell death protein 1 (PD …
Assessment of programmed death‐ligand 1 expression and tumor‐associated immune cells in pediatric cancer tissues
RG Majzner, JS Simon, JF Grosso, D Martinez… - Cancer, 2017 - Wiley Online Library
BACKGROUND Programmed death 1 (PD‐1) signaling in the tumor microenvironment
dampens immune responses to cancer, and blocking this axis induces antitumor effects in …
dampens immune responses to cancer, and blocking this axis induces antitumor effects in …