Epithelial–mesenchymal transition (EMT) is a type of cellular plasticity by which epithelial
cells acquire the form and function of mesenchymal cells. Physiologic EMT is an essential …

Numerous studies demonstrate that the non-steroidal anti-inflammatory drug (NSAID)
Celecoxib is an attractive lead compound for cancer therapy: Epidemiological studies …

Background. Overcoming radioresistance is an important problem in radiation oncology.
Therefore, the development of new approaches to modeling the radiosensitivity of tumors in …

As the second most common cancer and the first leading cause of cancer deaths, lung
cancer attracts much research attention. Since cyclooxygenase-2 (COX-2) is overexpressing …

Supplementary Appendix 2 Page 1 Supplementary Appendix 2 Phase 3 clinical trials and
extracted data included in the analysis Trial Primary Endpoint Positive or Negative Stage/Setting …

[背景・目的] 抗悪性腫瘍薬の臨床試験において, 全生存期間 (OS) は, がん患者の臨床的
ベネフィットを示すための代表的かつ最も信頼されるエンドポイントである. 一方で, OS …

Tumor microenvironment consists in immune and inflammatory response cells, fibroblasts
and endothelial cells. Innate immunity induces inflammation and is the first non-specific line …

The Netherlands is a small European country with a population of 17.45 million (September
2020) distributed over 41,543 km2. 1 There are 79 hospitals (in total, 109 locations), of …

The tumor vasculature is an important target for anticancer therapy because the blood
vessels deliver oxygen and nutrients to whole-body, as well as provide a route for tumor …