Chemotherapy-induced peripheral neuropathy (CIPN) is the main dose-limiting adverse
effect of chemotherapy drugs such as paclitaxel (PTX). PTX causes marked molecular and …

Osteoarthritis (OA) is a chronic joint disease that represents an increasingly substantial
global burden. Joint pain is the most significant symptom of OA. Unfortunately, current …

The neural mechanism responsible for migraine remains unclear. While the role of an
external trigger in migraine initiation remains vigorously debated, it is generally assumed …

Paclitaxel-induced neuropathic pain (PINP) is a dose-limiting side effect and is refractory to
widely used analgesic drugs. Previous studies have demonstrated a protective role of …

Neuronal processes (neurites and axons) have an important role in brain cells
communication and, generally, they are damaged in neurodegenerative diseases. Recent …

Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of
hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having …

Pioglitazone, an agonist at peroxisome proliferator-activated receptor gamma, is FDA-
approved for the treatment of insulin resistance in type 2 diabetes. Numerous studies in …

Repeated administration of peroxisome proliferator–activated receptor gamma (PPARg)
agonists reduces neuropathic pain-like behavior and associated changes in glial activation …

Neuropathic pain takes a heavy toll on individual well-being, while current therapy is far from
desirable. Herein, we assessed the analgesic effect of β-elemene, a chief component in the …

Dissecting the organization of circuit pathways involved in pain affect is pivotal for
understanding behavior associated with noxious sensory inputs. The central nucleus of the …