Effective, non-addictive therapeutics for chronic pain remain a critical need. While there are
several potential therapeutics that stimulate anti-inflammatory mechanisms to restore …

Neuropathic pain caused by nervous system damage or system dysfunction. The
pathogenesis and the mechanism underlying neuropathic pain remains unclear. The only …

Denervation of skeletal muscle is a debilitating consequence of injury of the peripheral
nervous system, causing skeletal muscle to experience robust atrophy. However, the …

Chemotherapy‐induced neuropathy is a disabling pain condition resulting from
chemotherapy for cancers. Up to now, no drug is available to cure chemotherapy‐induced …

Since the advent of anatomical brain imaging analysis techniques, numerous reports have
shown altered regional brain anatomy in individuals with various chronic pain conditions …

Bone cancer pain (BCP) is a severe type of hyperpathic pain occurring with primary bone
tumors or advanced cancers which metastasize to bones. BCP can detrimentally reduce …

Microglia are important cells involved in the regulation of neuropathic pain (NPP) and
morphine tolerance. Information on their plasticity and polarity has been elucidated after …

Editorial Views restored the rosiglitazone-mediated shift of macrophage phenotype from M1
to M2, attenuation of neutrophil infiltration, and macrophage clearance of apoptotic …

Background Although decanoic acid (DA) is thought to act as a muscarinic cholinergic
agonist, effect of DA on nociceptive behavioral responses and the excitability of nociceptive …

Across all cultures, patients with chronic pain have among the lowest reported quality‐of‐life
scores of any medical condition and have comorbid mood or anxiety disorders more …