Abstract Approximately 22% of the United States population suffers from a chronic orofacial
pain condition. One such condition is known as trigeminal neuropathic pain frequently …

The aim of this study is to investigate the role of peroxisome proliferator-activated receptor-
gamma isoform (PPARy), in trigeminal neuropathic pain utilizing a novel mouse trigeminal …

As dores crônicas representam um grande problema de saúde pública, sendo o sexo
feminino mais afetado. Como estratégia farmacológica ao controle da dor, os ligantes de …

Neuropathic pain affects up to 50% of the 29 million diabetic patients in the United States.
Neuropathic pain in diabetes manifests as a disease of the peripheral and central nervous …

There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Abstract: This work was designed to investigate the antinociceptive effects of combinations
of pioglitazone or metformin with fluoxetine in acute and persistent pain models in Swiss …

Chronic pain is a common complication of diabetes. he aim of the present study was to
characterise pain behaviour in a high fat diet/streptozotocin (HFD/STZ) model of diabetes in …

Background and Purpose: Epoxyeicosatrienoic acids (EETs), arachidonic acid-derived 25
cytochrome P450 (CYP) epoxygenase metabolites, have diverse biological effects including …