The phenotypic markers of colorectal carcinomas with microsatellite instability have been
widely studied and include mucinous or poor differentiation, prominent host response, a …

Colorectal cancer (CRC) can progress through two pathways of genomic instability:
chromosomal (CIN) and microsatellite instability (MSI). We hypothesized that these two …

Simple Summary Immunotherapy has reshaped the prognosis of several tumor types. In
metastatic colorectal cancer, only tumors with microsatellite instability or mismatch repair …

Purpose: Immunohistochemistry (IHC) and microsatellite instability (MSI) analysis can be
used to identify patients with a possible DNA mismatch repair defect [hereditary …

Identification of colorectal carcinomas with high levels of DNA microsatellite instability (MSI-
H) is important because of the suggested prognostic and therapeutic significance associated …

Background: Colorectal cancers resulting from defective DNA mismatch repair can occur in
both hereditary non-polyposis colon cancer (HNPCC) and in the sporadic setting. They are …

Lynch syndrome (LS) is an autosomal dominant cancer predisposition syndrome attributable
to deleterious germline mutations in mismatch repair (MMR) genes. The syndrome is typified …

Poor histological differentiation is currently considered among the adverse histopathological
factors associated with unfavourable clinical course of colorectal carcinoma (CRC). At …

Background & aims: The risk for small bowel cancer (SBC) is significantly increased in
hereditary nonpolyposis colorectal cancer (HNPCC). HNPCC-associated SBCs are poorly …

Background&Aims: Germline mutations in the DNA mismatch repair (MMR) genes MSH2,
MSH6, or MLH1 predispose to colorectal cancer (CRC) with an autosomal dominant …