Heterocyclic anticancer compounds: recent advances and the paradigm shift towards the use of nanomedicine's tool box

P Martins, J Jesus, S Santos, LR Raposo… - Molecules, 2015 - mdpi.com
The majority of heterocycle compounds and typically common heterocycle fragments
present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility …

Gold nanotheranostics: proof-of-concept or clinical tool?

P Pedrosa, R Vinhas, A Fernandes, PV Baptista - Nanomaterials, 2015 - mdpi.com
Nanoparticles have been making their way in biomedical applications and personalized
medicine, allowing for the coupling of diagnostics and therapeutics into a single …

Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of Gold Nanoparticles

R Mendes, P Pedrosa, JC Lima, AR Fernandes… - Scientific Reports, 2017 - nature.com
Photothermal Therapy (PTT) impact in cancer therapy has been increasing due to the
enhanced photothermal capabilities of a new generation of nanoscale photothermal agents …

[图书][B] Application of nanotechnology in drug delivery

AD Sezer - 2014 - books.google.com
This book collects reviews and original articles from eminent experts working in the
interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent …

Gold nanoparticles loaded chitosan encapsulate 6-mercaptopurine as a novel nanocomposite for chemo-photothermal therapy on breast cancer

AH Faid, SA Shouman, YA Badr, M Sharaky… - BMC chemistry, 2022 - Springer
Background As a promising strategy to overcome the therapeutic disadvantages of 6-
mercaptopurine (6MP), we proposed the encapsulation of 6MP in chitosan nanoparticles …

Gold nanoparticle approach to the selective delivery of gene silencing in cancer—the case for combined delivery?

R Mendes, AR Fernandes, PV Baptista - Genes, 2017 - mdpi.com
Gene therapy arises as a great promise for cancer therapeutics due to its potential to silence
genes involved in tumor development. In fact, there are some pivotal gene drivers that suffer …

[HTML][HTML] Photothermal nanomaterials for theranostics of atherosclerosis and thrombosis

KX Vazquez-Prada, SS Moonshi, ZP Xu, HT Ta - Applied Materials Today, 2023 - Elsevier
Nonradiative therapies focusing on converting energy from light into heat (photothermal
therapy, PTT) have been widely studied for the treatment of cancers. In the last years …

Light irradiation of gold nanoparticles toward advanced cancer therapeutics

A Amendoeira, LR García, AR Fernandes… - Advanced …, 2020 - Wiley Online Library
Cancer is one of the leading causes of death in the world. To challenge this epidemic, there
are growing demands for the development of new advanced and targeted therapeutics …

Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells

P Pedrosa, R Mendes, R Cabral, LM Martins… - Scientific Reports, 2018 - nature.com
Despite great advances in the fight against cancer, traditional chemotherapy has been
hindered by the dose dependent adverse side effects that reduce the usable doses for …

Anti-cancer precision theranostics: a focus on multifunctional gold nanoparticles

RM Cabral, PV Baptista - Expert review of molecular diagnostics, 2014 - Taylor & Francis
Gold nanoparticles have been appointed as cutting-edge platforms for combined diagnostic
and therapeutic approaches due to their exquisite physicochemical and optical properties. In …