[HTML][HTML] Lipoprotein abnormalities in South Asians and its association with cardiovascular disease: current state and future directions
O Bilen, A Kamal, SS Virani - World journal of cardiology, 2016 - ncbi.nlm.nih.gov
South Asians have a high prevalence of coronary heart disease (CHD) and suffer from early-
onset CHD compared to other ethnic groups. Conventional risk factors may not fully explain …
onset CHD compared to other ethnic groups. Conventional risk factors may not fully explain …
Association of interleukin 6 receptor variant with cardiovascular disease effects of interleukin 6 receptor blocking therapy: a phenome-wide association study
Importance Electronic health record (EHR) biobanks containing clinical and genomic data
on large numbers of individuals have great potential to inform drug discovery. Individuals …
on large numbers of individuals have great potential to inform drug discovery. Individuals …
Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease
Background Familial hypobetalipoproteinemia is a genetic disorder caused by rare protein-
truncating variants (PTV) in the gene encoding APOB (apolipoprotein B), the major protein …
truncating variants (PTV) in the gene encoding APOB (apolipoprotein B), the major protein …
Targeted next-generation sequencing in monogenic dyslipidemias
RA Hegele, MR Ban, H Cao, AD McIntyre… - Current opinion in …, 2015 - journals.lww.com
Targeted next-generation sequencing in monogenic dyslipidemi... : Current Opinion in
Lipidology Targeted next-generation sequencing in monogenic dyslipidemias : Current …
Lipidology Targeted next-generation sequencing in monogenic dyslipidemias : Current …
Progress and perspectives in plant sterol and plant stanol research
Current evidence indicates that foods with added plant sterols or stanols can lower serum
levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and …
levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and …
Liver X receptors at the intersection of lipid metabolism and atherogenesis
SD Lee, P Tontonoz - Atherosclerosis, 2015 - Elsevier
Cholesterol homeostasis is maintained through the coordinated regulation of the trafficking,
biosynthesis, absorption, and efflux of cholesterol. From the discovery that atherosclerotic …
biosynthesis, absorption, and efflux of cholesterol. From the discovery that atherosclerotic …
Sex differences in familial hypercholesterolemia
M Klevmoen, JWCM Mulder… - Current Atherosclerosis …, 2023 - Springer
Abstract Purpose of Review This review aims to summarize the existing research on sex
differences in familial hypercholesterolemia (FH) across the lifespan. Recent Findings From …
differences in familial hypercholesterolemia (FH) across the lifespan. Recent Findings From …
Intensive lipid-lowering therapy for early achievement of guideline-recommended LDL-cholesterol levels in patients with ST-elevation myocardial infarction (“Jena auf …
U Makhmudova, B Samadifar, A Maloku… - Clinical Research in …, 2023 - Springer
Background and aims Currently, less than 20% of patients at very high-risk achieve
ESC/EAS dyslipidemia guideline-recommended LDL-C target levels in Europe.“Jena auf …
ESC/EAS dyslipidemia guideline-recommended LDL-C target levels in Europe.“Jena auf …
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
RA Scott, DF Freitag, L Li, AY Chu… - Science translational …, 2016 - science.org
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should
not be associated with an unacceptable increase in cardiovascular risk. Human genetics …
not be associated with an unacceptable increase in cardiovascular risk. Human genetics …
Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease
Background: Familial sitosterolemia is a rare Mendelian disorder characterized by
hyperabsorption and decreased biliary excretion of dietary sterols. Affected individuals …
hyperabsorption and decreased biliary excretion of dietary sterols. Affected individuals …