South Asians have a high prevalence of coronary heart disease (CHD) and suffer from early-
onset CHD compared to other ethnic groups. Conventional risk factors may not fully explain …

Importance Electronic health record (EHR) biobanks containing clinical and genomic data
on large numbers of individuals have great potential to inform drug discovery. Individuals …

Background Familial hypobetalipoproteinemia is a genetic disorder caused by rare protein-
truncating variants (PTV) in the gene encoding APOB (apolipoprotein B), the major protein …

Targeted next-generation sequencing in monogenic dyslipidemi... : Current Opinion in
Lipidology Targeted next-generation sequencing in monogenic dyslipidemias : Current …

Current evidence indicates that foods with added plant sterols or stanols can lower serum
levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and …

Cholesterol homeostasis is maintained through the coordinated regulation of the trafficking,
biosynthesis, absorption, and efflux of cholesterol. From the discovery that atherosclerotic …

Abstract Purpose of Review This review aims to summarize the existing research on sex
differences in familial hypercholesterolemia (FH) across the lifespan. Recent Findings From …

Background and aims Currently, less than 20% of patients at very high-risk achieve
ESC/EAS dyslipidemia guideline-recommended LDL-C target levels in Europe.“Jena auf …

Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should
not be associated with an unacceptable increase in cardiovascular risk. Human genetics …

Background: Familial sitosterolemia is a rare Mendelian disorder characterized by
hyperabsorption and decreased biliary excretion of dietary sterols. Affected individuals …